Trap–neuter–return (TNR), also known as trap–neuter–release, is a controversial method that attempts to manage populations of feral cats. The process involves live-trapping the cats, having them neutered, ear-tipped for identification, and, if possible, vaccinated, then releasing them back into the outdoors. If the location is deemed unsafe or otherwise inappropriate, the cats may be relocated to other appropriate areas (barn/farmyard homes are often considered best). Ideally, friendly adults and kittens young enough to be easily socialized are retained and placed for adoption. Feral cats cannot be socialized, shun most human interaction and do not fare well in confinement, so they are not retained. Cats suffering from severe medical problems such as terminal, contagious, or untreatable illnesses or injuries are often euthanized.

In the past, the main goal of most TNR programs was the reduction or eventual elimination of free-roaming cat populations. It is still the most widely implemented non-lethal method of managing them. While that is still a primary goal of many efforts, other programs and initiatives may be aimed more towards providing a better quality of life for feral cats, stemming the population expansion that is a direct result of breeding, improving the communities in which these cats are found, reducing "kill" rates at shelters that accept captured free-roaming cats, in turn improving public perceptions and possibly reducing costs, and eliminating or reducing nuisance behaviors to decrease public complaints about free-roaming cats.

Scientific research has not found TNR to be an effective means of controlling the feral cat population. Literature reviews have found that when studies documented TNR colonies that declined in population, those declines were being driven primarily by substantial percentages of colony cats being permanently removed by a combination of rehoming and euthanasia on an ongoing basis, as well as by an unusually high rate of death and disappearance. TNR colonies often increase in population because cats breed quickly and the trapping and sterilization rates are frequently too low to stop this population growth, because food is usually being provided to the cats, and because public awareness of a TNR colony tends to encourage people in the surrounding community to dump their own unwanted pet cats there. The growing popularity of TNR, even near areas of particular ecological sensitivity, has been attributed in part to a lack of public interest regarding the environmental harm caused by feral cats, and the unwillingness of both scientific communities and TNR advocates to engage.